Showing posts with label PETS AND RSV. Show all posts
Showing posts with label PETS AND RSV. Show all posts

STUDY FINDS PETS REDUCE THE RISK OF DEVELOPING ALLERGIES AND OBESITY

USA TODAY Published 11:51 a.m. ET April 7, 2017 | Updated 12:38 p.m. ET April 7, 2017

A study at the University of Alberta in Canada found that being exposed to pets early in life may reduce the risk of developing allergies and obesity. Researchers found that babies from families with pets, especially dogs, had higher levels of two types of microbes that are known to lower risks of allergies and obesity. 
Families with cats or dogs running around the house may unwittingly be protecting their infant children from future allergies and obesity.
Research out of Canada shows babies born into families with pets have higher amounts of microbes tied to lower risks of obesity and allergies.
University of Alberta epidemiologist Anita Kozyrskyj and a team of researchers analyzed more than 700 Canadian children. They found babies exposed to pets while in the womb or up to three months recorded an "abundance" of ruminococcus and oscillospira, the latter of which is associated with leanness or lower body mass index, notes the study published in the journal Microbiome.
Kozyrskyj said the two types of bacteria increased "twofold" when a pet was in the house. The team said the theory is that early exposure to bacteria — like that from a dog — creates a type of resistance.
Kozyrskyj said unborn babies and newborns often are indirectly exposed, with the microbes passing from pet, to mother to baby. This means a child could get the benefits of the microbes even if the pet were removed from the home before the baby was born.
The findings also suggest pet exposure could cut down the risk of group B strep, which the Centers for Disease Control and Prevention said could cause blood infection, pneumonia and meningitis in newborns. Doctors treat against group B strep by giving mothers antibiotics during the delivery process.
Kozyrrskyj said she wouldn't be surprised if the pharmaceutical industry created a "dog in a pill" to reap the benefits of the microbes.
Article found here.

PETS AND RSV

House dust from homes with dogs appears to protect against infection with a common respiratory virus that is associated with the development of asthma in children. Researchers from the University of California, San Francisco, present their findings today at the 2012 General Meeting of the American Society for Microbiology.

"In this study we found that feeding mice house dust from homes that have dogs present protected them against a childhood airway infectious agent, respiratory syncytial virus (RSV). RSV infection is common in infants and can manifest as mild to severe respiratory symptoms. Severe infection in infancy is associated with a higher risk of developing childhood asthma," says Kei Fujimura, a researcher on the study.

In the study Fujimura and her colleagues compared three groups of animals: Mice fed house dust from homes with dogs before being infected with RSV, mice infected with RSV without exposure to dust and a control group of mice not infected with RSV.

"Mice fed dust did not exhibit symptoms associated with RSV-mediated airway infection, such as inflammation and mucus production. They also possessed a distinct gastrointestinal bacterial composition compared to animals not fed dust," says Fujimura.

Pet ownership, in particular dogs, has previously been associated with protection against childhood asthma development, says Fujimura. Recently she and her colleagues demonstrated that the collection of bacterial communities (the microbiome) in house dust from homes that possess a cat or dog is compositionally distinct from house dust from homes with no pets.

"This led us to speculate that microbes within dog-associated house dust may colonize the gastrointestinal tract, modulate immune responses and protect the host against the asthmagenic pathogen RSV," says Fujimura. "This study represents the first step towards determining the identity of the microbial species which confer protection against this respiratory pathogen."

Identification of the specific species and mechanisms underlying this protective effect represents a crucial step towards understanding the critical role of microbes in defining allergic disease outcomes and could lead to development of microbial-based therapies to protect against RSV and ultimately reduce the risk of childhood asthma development, says Fujimura.

This work represents a collaboration between the Lynch lab at University of California San Francisco and the Lukacs lab at the University of Michigan, Ann Arbor. Tine Demoor, a post-doc in Nick Lukacs lab, performed the mouse experiments and measured airway symptomology associated with RSV infection. Fujimura, Marcus Rauch, and Stephanie Galang from Susan Lynch's group performed microbiome profiling and data analysis of cecal (gut) contents from these animals.

This research was presented as part of the 2012 General Meeting of the American Society for Microbiology held June 16-19, 2012 in San Francisco, California. A full press kit for the meeting, including tipsheets and additional press releases, can be found online at http://bit.ly/asm2012pk

The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.